Abstract:

The escalating challenge of antimicrobial resistance (AMR) has intensified the search for novel bioactive compounds capable of combating multidrug-resistant pathogens. The genus Actinomyces, known for its prolific production of secondary metabolites, has emerged as a promising source of new antimicrobial agents. This study explores the antimicrobial efficacy of Actinomyces strains, focusing on their potential to produce antibacterial and antifungal compounds. Through a comprehensive approach involving isolation, culturing, and bioactivity assessment, selected Actinomyces strains were evaluated for their ability to inhibit the growth of various pathogenic bacteria and fungi. The results demonstrated significant antimicrobial activity, with several isolates exhibiting broad-spectrum effects against both Gram-positive and Gram-negative bacteria, as well as potent antifungal properties. The study also highlights the diverse biosynthetic pathways within Actinomyces that contribute to the production of unique bioactive compounds. These findings underscore the potential of Actinomyces as a valuable resource in the ongoing quest for effective antimicrobial agents and provide a foundation for future research into novel drug discovery to address the global AMR crisis.

Description:

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